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Researchers found glucagon, a hormone involved in regulating appetite, loses its ability to help obese people feel full after a meal, but it continues to suppress hunger pangs in people with type 1 diabetes.
But growing evidence suggests the hormone may also play a role in controlling food intake and feelings of fullness, or satiation, through signalling the body to reduce levels of other appetite hormones such as ghrelin.
The study, published in the Journal of Clinical Endocrinology and Metabolism, investigated glucagon levels and appetite among 11 obese people, 13 of whom had type 1 diabetes and 13 lean people who received injections of either glucagon or a placebo.
Growing evidence suggests glucagon may also play a role in controlling food intake and feelings of fullness, or satiation, through signalling the body to reduce levels of other appetite hormones such as ghrelin 'Although therapeutic agents that influence glucagon and other hormones currently are considered a promising avenue for research, this study suggests a treatment involving glucagon may be ineffective in controlling meal size in people who are obese.'When glucagon is released it stimulates the liver to break down glycogen to be released into the blood as glucose, activates gluconeogenesis, (the conversion of amino acids into glucose) and breaks down stored fat into fatty acids for use as fuel by cells.
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In people with diabetes, the presence of glucagon can push blood glucose levels too high because wither not enough insulin is present or in the case of type 2 diabetes, the body is not very good at responding to insulin.
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